HLA-DRB4, NT (HLA-DRB4, HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4), 036625-200ul


HLA-DRB4, NT (HLA-DRB4, HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4), 036625-200ul by United States Biological at Periodic Table on the Web. MPN: 036625. Hurry! Limited time offer. Offer valid only while supplies last. HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the lead


HLA-DRB4, NT (HLA-DRB4, HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4), 036625-200ul by United States Biological
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Availability: In Stock
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Product Description & Reviews

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Features & Highlights

  • Pab
  • Recognizes human HLA-DRB4.
  • Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
  • Purified by Protein A affinity chromatography.

Additional Information

Brand:
United States Biological
Manufacturer:
United States Biological
Category:
Antigens
MPN:
036625
Part Number:
036625
Publisher:
United States Biological
Item Weight:
0.01 pounds

 


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